Novel Nanoparticle Contrast Agents for Magnetic Resonance Imaging

ORAL

Abstract

Magnetic resonance imaging (MRI) is an important diagnostic tool in both clinical and research environments. In order to improve sensitivity, contrast agents (CAs) are often administered prior to or during imaging sessions. We have developed a number of novel nanoparticle CAs consisting of metal-oxo clusters with high spins (molecular magnets) encapsulated in polymer nanocarriers. The pure clusters show good relaxivities, which can be further enhanced by encapsulation in the polymers. In some cases, values of the relaxivity comparable to or larger than those of commercially available CAs can be achieved. We will report on the contrast enhancement from several of these nanoparticles in both phantom and in vivo images.

*Funding for this work was provided through grant R15EB025538 from the National Institutes of Health

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Publication: T. Lyons, C. Kekedjian, P. Glaser, C. Ohlin, R. van Eldik, O. Rodriguez, C. Albanese, E Van Keuren, S. Stoll, Molecular Parameters promoting high relaxivity in cluster-nanocarrier MRI contrast agents", ACS Applied Materials & Interfaces, accepted for publication Oct. 2022.
Vidumin Dahanayake, Trevor Lyons, Brendan Kerwin, Olga Rodriguez, Christopher Albanese, Erika Paradiso, Yichien Lee, Edward Van Keuren, Luxi Li, Evan Maxey, Tatjana Paunesku, Gayle Woloschak, and Sarah L. Stoll, "Paramagnetic Mn8Fe4-co-Polystyrene Nanobeads as a Potential T1-T2 Multi-Modal MRI Contrast Agent with in vivo Integrity" ACS Applied Materials and Interfaces, 13 (2021) 39042.
V. Dahanayake, C. Pornrungroj, M. Pablico-Lansigan, W. J. Hickling, T. Lyons, D. Lah, Y. Lee, E. Parasido, J. Bertke, C. Albanese, O. Rodriguez, E. Van Keuren, and S.L. Stoll "Paramagnetic Clusters of Mn-3(O2CCH3)(6)(Bpy)(2) in Polyacrylamide Nanobeads as a New Design Approach to a T-1-T-2 Multimodal Magnetic Resonance Imaging Contrast Agent" ACS Applied Materials & Interfaces, 11 (2019) 18153-18164

Presenters

  • Edward R Van Keuren

    • Georgetown University

Authors

  • Edward R Van Keuren

    • Georgetown University

  • Sarah Stoll

    • Georgetown University

  • Trevor Lyons

    • Georgetown University

  • Chloe Kekedjian

    • Georgetown University

  • Christopher Albanese

    • Georgetown University

  • Olga Rodriguez

    • Georgetown University

  • Stanley Fricke

    • Georgetown University

  • Orelle Bulgin

    • Georgetown University