Physics of the Immune System I: From Repertoire to Function
FOCUS · Q36 · ID: 2154447
Presentations
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Learning the shape of the immune and protein universe
ORAL · Invited
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Publication: M.N. Pun, A. Ivanov, Q. Bellamy, Z. Montague, C. LaMont, P. Bradley, J. Otwinowski, A. Nourmohammad (2022) Learning the shape of protein micro-environments with a holographic convolutional neural network. arXiv:2211.02936v1
G.M. Visani, M.N. Pun, A. Nourmohammad (2022) Holographic-(V)AE: an end-to-end SO(3)-Equivariant (Variational) Autoencoder in Fourier Space. arXiv:2209.15567v2Presenters
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Armita Nourmohammad
- University of Washington
Authors
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Armita Nourmohammad
- University of Washington
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Michael N Pun
- University of Washington
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Gian Marco Visani
- University of Washington
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Andrew Ivanov
- University of Washington
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Quinn Bellamy
- University of Washington
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Zachary A Montague
- University of Washington
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Colin LaMont
- Max Planck Institute for Dynamics and Self-Organization
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Philip Bradley
- Fred Hutchinson Cancer Center
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Jakub Otwinowski
- Dyno Therapeutics
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Arman Angaji
- University of Cologne
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Learning evolutionary parameters from B-cell lineage trees.
ORAL
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Presenters
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Antoine Aragon
- PSL University
Authors
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Antoine Aragon
- PSL University
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Aleksandra M Walczak
- CNRS
- CNRS, LPENS
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Thierry Mora
- LPENS
- Ecole Normale Superieure
- CNRS
- CNRS, LPENS
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Amaury Lambert
- CNRS
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Biophysical modeling for accurate and efficient predictions of T cell-antigen specificity
ORAL
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Publication: Planned paper: Wang A, Lin X, Ng Chau K, Onuchic JN, Levine H, George JT. BioRxiv doi: 10.1101/2023.08.06.552190.
Presenters
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Jason T George
- Texas A&M University
Authors
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Jason T George
- Texas A&M University
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How different are self and nonself?
ORAL
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Publication: Mayer, A., Russo, C.J., Marcou, Q., Bialek, W. and Greenbaum, B.D., 2022. How different are self and nonself?. arXiv preprint arXiv:2212.12049.
Presenters
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Benjamin Greenbaum
- Memorial Sloan Kettering Cancer Center
Authors
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Benjamin Greenbaum
- Memorial Sloan Kettering Cancer Center
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Andreas Mayer
- UCL
- University College London
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Christopher Joel Russo
- University of Chicago
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Quentin Marcou
- Aix-Marseille Université
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William S Bialek
- Princeton University
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Signatures of Functional Immune Responses to Acute and Chronic COVID-19 Infections
ORAL
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Presenters
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Rhea M Grover
- University of California, Berkeley; University of Washington
Authors
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Rhea M Grover
- University of California, Berkeley; University of Washington
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Zachary A Montague
- University of Washington
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Assya Trofimov
- Fred Hutch Cancer Center; University of Washington
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Andrew Baumgartner
- Institute for Systems Biology
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Jennifer Hadlock
- Institute for Systems Biology
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Armita Nourmohammad
- University of Washington
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Optimizing Multi-Dose Vaccination Protocols for Enhanced Viral Infection Defense
ORAL
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Presenters
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Saeed Mahdisoltani
- Massachusetts Institute of Technology
Authors
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Saeed Mahdisoltani
- Massachusetts Institute of Technology
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Sam Melton
- Massachusetts Institute of Technology
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Mehran Kardar
- Massachusetts Institute of Technology MI
- Massachusetts Institute of Technology
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Arup K Chakraborty
- MIT
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Real-time immune recognition in a primary acute infection
ORAL
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Publication: R. Morán-Tovar and M. Lässig, Non-equilibrium antigen recognition in acute infections, arXiv, arXiv:2304.02794v3, 2023.
Presenters
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Roberto Morán-Tovar
- University of Cologne
Authors
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Roberto Morán-Tovar
- University of Cologne
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Michael Lässig
- University of Cologne
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Dynamic role of T follicular helper cells in shaping B cell affinity maturation
ORAL
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Presenters
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Andrew G Pyo
- Princeton University
Authors
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Andrew G Pyo
- Princeton University
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Julia Merkenschlager
- Rockefeller University
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Ned S Wingreen
- Princeton University
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Computational HLA typing from repertoires
ORAL
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Publication: Planned paper
Presenters
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Maria Ruiz Ortega
- CNRS/ENS Paris
Authors
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Maria Ruiz Ortega
- CNRS/ENS Paris
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Thierry Mora
- Ecole Normale Superieure de Paris
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Aleksandra Walczak
- Ecole Normales Superieure de Paris
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Mikhail Pogorelyy
- St. Jude Children's Research Hospital
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Anastasia Minervina
- St. Jude Children's Research Hospital
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Paul Thomas
- St. Jude Children's Research Hospital
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Computational detection of antigen-specific B-cell receptors
ORAL
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Presenters
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Maria Francesca Abbate
- École normal supérieure Paris-Saclay
Authors
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Maria Francesca Abbate
- École normal supérieure Paris-Saclay
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Aleksandra M Walczak
- CNRS
- CNRS, LPENS
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Thierry Mora
- LPENS
- Ecole Normale Superieure
- CNRS
- CNRS, LPENS
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Melody Shahsavarian
- Sanofi
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Binding affinity landscapes of broadly neutralising antibodies
ORAL
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Publication: 1. Phillips, A. M. et al. Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies. eLife 10, e71393 (2021).
2. Phillips, A. M. et al. Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody. eLife 12, e83628 (2023).
Presenters
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Thomas Dupic
- Harvard
Authors
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Thomas Dupic
- Harvard
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Angela M Phillips
- UCSF
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Alief Moulana
- Harvard
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Michael Desai
- Harvard
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Katherine R Lawrence
- Harvard
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Thierry Mora
- LPENS
- Ecole Normale Superieure
- CNRS
- CNRS, LPENS
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Aleksandra M Walczak
- CNRS
- CNRS, LPENS
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T cells Function and Similarity- predictions from statistical and network analysis of the immune repertoire
ORAL
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Presenters
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Yuval Elhanati
- Memorial Sloan Kettering Cancer Center
Authors
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Yuval Elhanati
- Memorial Sloan Kettering Cancer Center
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Benjamin Greenbaum
- Memorial Sloan Kettering Cancer Center
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Andreas Mayer
- UCL
- University College London
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Immune control of the gut microbiota via avoidance and tolerance
ORAL
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Presenters
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Obinna A Ukogu
- University of Washington
Authors
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Obinna A Ukogu
- University of Washington
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Armita Nourmohammad
- University of Washington
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