A New Physical Model and Anti-Fog Technology for Undistorted Visualization through Endoscope Lenses using Sterile, Benign, Hyper-Hydrophilic Gel Coatings to Planarize and Absorb Condensing Water

ORAL

Abstract

Fogging on endoscope lenses limits visualization in closed body cavity surgery, due to differences in body temperatures vs Operating Rooms (OR). Surgeons have to remove and reinsert endoscopes, which increases infections, scarring, surgery durations, and costs.

Fogging is due to discontinuous 3D films formed by (hemi-) spherical drops refracting light.

The present anti-fog model and technology, KnoxFog™, uses hyper-hydrophilic [1] coatings. Hyper-hydrophilicity combines super-hydrophilicity [2-4] with "absorbing nanopores".

Super-hydrophilicity condenses water into continuous, flat, clear 2-D film [2] . Absorbing nanopores consist of a uniform hydrophilic network of nanopores drawing molecules into the material, which evacuates condensating water by molecular absorption. Combining super-hydrophilicity with absorbing nanopores maintains condensating water films flat and uniform, free of optical distortion, and inhibits water runoff into large drops. Hyper-hydrophilicity impedes two types of droplet formation – fog and run-off.

Current anti-fog strategies are insufficient. Acidic and alcohol-based anti-fog solutions quickly evaporate. Heating endoscopes requires reheating every 5 to 40 min [2, 4-8].

Hyper-hydrophilic KnoxFog™ is applied as a solid gel via a small, sterile, reusable, applicator, ClearEndoscope™, and dries in seconds.

In vitro comparison with eight endoscopes shows imaging is fog-free for hours with KnoxFog™ vs bare lenses, lens heating and other anti-fogs.

*Funding by Infinitum BioMed LLC, SiO2 Innovates LLC, and UV One Hygienics Inc. are here gratefully acknowledged.

Publication: [1] Herbots, N., Russell-Hill, M.I., Suppes, D.D.,
FOG ELIMINATION SYSTEMS FOR ENDOSCOPIC LENSES, INCLUDING SURGICAL SCOPES, STERILIZING APPLICATORS AND ANTI-FOG COATINGS
US Patent Pending (2023)

[2] Herbots, N. et al.
"SUPER-HYDROPHILIC, BIO-COMPATIBLE ANTI-FOG COATING FOR LENSES IN CLOSED BODY CAVITY SURGERY..."
MRS Advances 1, 2141–2146 (2016)
DOI: https://doi.org/10.1557/adv.2016.474

[3] Herbots, N., Russell-Hill, M.I., Suppes, D.D., Suresh, A. P., Prakash, S. T., Swaminathan, S. J., Swaminathan, V. J., Thinakaran, A., Amin, V. Y. V., Rane, R. N., Jimenez, N. T., Dancho, E. B., Sreepathy, R.,
AN EXPERIMENTAL STUDY AND MODELING OF WATER CONDENSATION TO ELIMINATE FOGGING ON ENDOSCOPE LENSES, USING NEW HYPER-HYDROPHILIC COATINGS CALLED KNOXFOGTM
to be submitted to BioInterphases, J. of Biomaterials and Biological Interphases, publ. by the American Vacuum Society, AIP (2023)

[4] Izzati Fatimah Wahab, A.R. Bushroa, Soon Wee Teck, Taium Tasneem Azmi, M.Z. Ibrahim, J.W. Lee,
FUNDAMENTALS OF ANTIFOGGING STRATEGIES, COATING TECHNIQUES AND PROPERTIES OF INORGANIC MATERIALS; A COMPREHENSIVE REVIEW
Journal of Materials Research and Technology, Volume 23, 2023, Pages 687-714,
https://doi.org/10.1016/j.jmrt.2023.01.015

[5] Domke, M., Sonderegger, G., Kostal, E., Matylitsky V., Stroj S.,
TRANSPARENT LASER-STRUCTURED GLASSES WITH SUPER-HYDROPHILIC PROPERTIES FOR ANTI-FOGGING
APPLICATIONS.
Appl. Phys. A 125, 675 (2019).
DOI:10.1007/s00339-019-2953-6

[6] Song T, Lee DH.
A RANDOMIZED COMPARISON OF LAPARASCOPIC LENS DEFOGGING USING ANTI-FOG SOLUTION, WARM, SALINE, AND
CHLORHEXIDINE SOLUTION (CLEAR).
Surg Endosc. 2020 Feb;34(2):940-945.
doi: 10.1007/s00464-019-06852-5. Epub 2019 May 28. PMID: 31139989

[7] Manning TG, Papa N, Perera M, McGrath S, Christidis D, Khan M, O'Beirne R, Campbell N, Bolton D, Lawrentschuk N.
LAPARASCOPIC LENS FOGGING: SOLVING A COMMON SURGICAL PROBLEM IN STANDARD AND ROBOTIC LAPARASCOPES VIA A SCIENTIFIC MODEL
Surg Endosc. 2018 Mar;32(3):1600-1606.
doi: 10.1007/s00464-017-5772-x. Epub 2017 Aug 8. PMID: 28791559

[8] Merkx R, Muselaers C, d'Ancona F, Warlé M, van der Jagt M, Kusters A, Poyck P, Schulte R, Langenhuijsen J.
EFFECTIVENESS OF HEATED STERILE VS RESOCLEAR® FOR PREVENTION OF LAPARASCOPIC LENS FOGGING IN A RANDOMIZED COMPARATIVE TRIAL.
J Endourol. 2018 Jan;32(1):54-58.
doi: 10.1089/end.2017.0683. Epub 2018 Jan 3. PMID: 29186976

Presenters

  • Visweshwar G Swaminathan

    • Arizona State University

Authors

  • Visweshwar G Swaminathan

    • Arizona State University
  • Ashwin Suresh

    • Infinitum BioMed / SiO2 Innovates LLC/ UV One Hygienics Inc.
  • Viraj Y Amin

    • Arizona State University
  • Srivatsan J Swaminathan

    • Infinitum BioMed / SiO2 Innovates LLC/ UV One Hygienics Inc.
  • Shreyash T Prakash

    • Arizona State University
  • Nimith Gurijala

    • Arizona State University
  • Aarush Thinakaran

    • Infinitum BioMed/ SiO2 Innovates/ Arizona State U. Physics
  • Rianna Rane

    • Arizona State University
  • Nicholas T Jimenez

    • Infinitum BioMed/ SiO2 Innovates LLC/ UV One Hygienics Inc.
  • Ethan B Dancho

    • Infinitum BioMed/ SiO2 Innovates LLC/ UV One Hygienics Inc.
  • Dora D Suppes

    • Infinitum BioMed LLC/ UV One Hygienics Inc.
  • Mark I Russell-Hill

    • Infinitum BioMed LLC/ UV One Hygienics Inc.
  • Nicole Herbots

    • Infinitum BioMed/ SiO2 Innovates/ Arizona State U. Physics