Geometric programming of collective sensing of neural cells

To maintain the normal functionality of multicellular organisms, cells will integrate the chemical or physical information sensed by receptors and respond collectively through information networks constructed by intercellular communication methods, for example, gap junctions, secreted factors, etc. This process, even though it is vital for maintaining normal biological processes, is still far from fully understood. In our research, we used cell micropatterning techniques to pattern cell colonies on a grid-shaped maze and we control the connection between each grid by narrow bridges occupied by a small number of cells. The design of experiments enabled us to manipulate the information pathway that cells use to communicate. We will investigate the cellular response under external chemical stimulation.