Physical characteristics of some intrinsically disordered proteins from simulation studies using mesoscale models

Simulation studies using mesoscale models of Intrinsically Disordered Proteins (IDPs) can provide important information regarding their role in various disease. A key aspect of modeling is to identify parameters of the model(s) so that not only they match with the available experimental data but have a broader range of applicability. We will report our simulation results using coarse-grained models of IDPs. First, we will compare our results with the existing results published in the literature, and then extend our studies for a few specific IDPs important in the context of cancer¹ and diabetes². We will invoke polymer physics ideas to describe these IDPs.

¹We thank Dr. Vladimir Uversky for discussions on IDPs related to cancer.

²We thank Dr. Robert Sladek for discussions on IDPs related to diabetes.