Critical growth of cerebral tissue in organoids: theory and experiments
ORAL
Abstract
We develop a Fokker-Planck theory of tissue growth with three types of cells (symmetrically
dividing, asymmetrically dividing and non-dividing) as main agents to study the growth dynamics
of human cerebral organoids. Fitting the theory to lineage tracing data obtained in next generation
sequencing experiments, we show that the growth of cerebral organoids is a critical process. We
derive analytical expressions describing the time evolution of clonal lineage sizes and show how
power-law distributions arise in the limit of long times due to the vanishing of a characteristic
growth scale.
dividing, asymmetrically dividing and non-dividing) as main agents to study the growth dynamics
of human cerebral organoids. Fitting the theory to lineage tracing data obtained in next generation
sequencing experiments, we show that the growth of cerebral organoids is a critical process. We
derive analytical expressions describing the time evolution of clonal lineage sizes and show how
power-law distributions arise in the limit of long times due to the vanishing of a characteristic
growth scale.
*European Union's Framework Programme for Research and Innovation Horizon 2020 (2014-2020) under the Marie Curie Skªodowska Grant Agreement Nr. 847548Special Research Programme (SFB) of the Austrian Science Fund (FWF), project number F78 P11
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Presenters
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Egor I Kiselev
- Technion – Israel Institute of Technology