Biomolecular Phase Separation I - Interactions, Thermodynamics and Mechanics
FOCUS · S06 · ID: 46258
Presentations
-
A Molecular View of Liquid-Liquid Phase Separation of Disordered Proteins
ORAL · Invited
–
Publication: 1. Zheng W*,Dignon GL*, Xu X, Regy RM, Best RB, Zheng W, Mittal J, "Molecular details of protein condensates probed by microsecond-long atomistic simulations",Journal of Physical Chemistry B,124, 11671-11679.
2. Schuster BS*,Dignon GL*, Jahnke CN, Simpkins AG, Hammer DA, Good MC, Mittal J, "Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine its Phase Separation Behavior",Proceedings of the National Academy of Sciences,117, 11421-11431.
3. Zheng W, Dignon GL, Brown M, Kim YC, Mittal J, "Hydropathy patterning complements charge patterning to describe conformational preferences of disordered proteins",Journal of Physical Chemistry Letters,11, 3408-415.
4. Dignon GL*, Zheng W*, Kim YC, Mittal J, "Temperature controlled liquid-liquid phase separation of disordered proteins",ACS Central Science,5, 821-830.
5. Dignon GL*, Zheng W*, Best RB, Kim YC, Mittal J, "Relation between single-molecule properties and phase behavior of intrinsically disordered proteins",Proceedings of theNational Academy of Sciences,115, 9929-9934.
6. Dignon GL*, Zheng W*, Kim YC, Best RB, Mittal J, "Sequence determinants of protein phase behavior from a coarse-grained model",PLOS Computational Biology,14,e1005941.Presenters
-
Gregory Dignon
- Stony Brook University (SUNY)
Authors
-
Gregory Dignon
- Stony Brook University (SUNY)
-
-
Liquid state theory study of the microstructure and phase behavior of protein condensates
ORAL
–
Presenters
-
Guang Shi
- University of Illinois at Urbana-Champaign
Authors
-
Guang Shi
- University of Illinois at Urbana-Champaign
-
Kenneth S Schweizer
- University of Illinois at Urbana-Champaign
- University of Illinois at Urbana-Champai
-
-
Phase separation vs aggregation behavior for model disordered proteins
ORAL
–
Publication: Ushnish Rana, Clifford P. Brangwynne, and Athanassios Z. Panagiotopoulos , "Phase separation vs aggregation behavior for model disordered proteins", J. Chem. Phys. 155, 125101 (2021) https://doi.org/10.1063/5.0060046
Presenters
-
Ushnish Rana
- Princeton University
Authors
-
Ushnish Rana
- Princeton University
-
Cliff Brangwynne
- Princeton University
-
Athanassios Panagiotopoulos
- Princeton University
-
-
Nucleation in multicomponent liquid mixtures
ORAL
–
Presenters
-
Andrej Kosmrlj
- Princeton University
- Princeton
Authors
-
Josep Bataller i Umbert
- Polytechnic University of Catalonia
-
Mikko Haataja
- Princeton University
-
Sheng Mao
- Peking University
-
Andrej Kosmrlj
- Princeton University
- Princeton
-
-
Thermodynamic stability and critical points in multicomponent mixtures with structured interactions
ORAL
–
Publication: Isabella R. Graf and Benjamin B. Machta. "Thermodynamic stability and critical points in multicomponent mixtures with structured interactions." (2021). https://arxiv.org/abs/2110.11332
Presenters
-
Isabella R Graf
- Yale University
Authors
-
Isabella R Graf
- Yale University
-
Benjamin B Machta
- Yale University
- Yale
-
-
Material properties of Rubisco-EPYC1 condensates in an algal pyrenoid model
ORAL
–
Presenters
-
Trevor K GrandPre
- Princeton University
Authors
-
Trevor K GrandPre
- Princeton University
-
Yaojun Zhang
- Princeton University
-
Andrew G Pyo
- Princeton University
-
Benjamin Weiner
- Rockefeller University
- Princeton University
-
Ned S Wingreen
- Princeton University
-
-
Sequence and stoichiometry dependence of surface properties of biomolecular condensates
ORAL
–
Presenters
-
Andrew G Pyo
- Princeton University
Authors
-
Andrew G Pyo
- Princeton University
-
Yaojun Zhang
- Princeton University
-
Ned S Wingreen
- Princeton University
-
-
Concentration-dependent structure, diffusion and viscosity in a model macromolecular crowder
ORAL
–
Presenters
-
Venketesh Thrithamara Ranganathan
- Memorial University of Newfoundland
Authors
-
Anand Yethiraj
- Memorial University of Newfoundland
-
Yun Liu
- National Institute of Standards and Tech
-
Venketesh Thrithamara Ranganathan
- Memorial University of Newfoundland
-
-
On the interplay between phase separation and aggregation
ORAL
–
Publication: On the interplay between phase separation and aggregation [in prep.]
Presenters
-
Giacomo Bartolucci
- Max Planck Institute for the Physics of Complex Systems
Authors
-
Giacomo Bartolucci
- Max Planck Institute for the Physics of Complex Systems
-
Thomas C Michaels
- Harvard University
-
Christoph A Weber
- University of Augsburg, Institute of Physics
- Institute of Physics, University of Augsburg
- Institute of Physics University of Augsburg
-
-
Dynamics of intrinsically disordered proteins and their droplet-like aggregates
ORAL
–
Presenters
-
Łukasz Mioduszewski
- Instytut Fizyki Pan
Authors
-
Marek Cieplak
- Institute of Physics Polish Academy of Sciences
-
Łukasz Mioduszewski
- Instytut Fizyki Pan
-
-
Phase behavior and kinetics in systems with random interactions
ORAL
–
Presenters
-
Martin Girard
- Max Planck Institute for Polymer Research
Authors
-
Martin Girard
- Max Planck Institute for Polymer Research
-
-
Computational design of amino-acid sequence variations that modulate the liquid-liquid phase separation of intrinsically disordered proteins
ORAL
–
Publication: - Joseph, Reinhardt et al., Physics driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy, Nat.Comput. Sci., 2021 (in press).
- Lichtinger et al, Targeted modulation of protein liquid–liquid phase separation by evolution of amino-acid sequence, Plos Comp Biol, 2021Presenters
-
Maria J Maristany
- Univ of Cambridge
Authors
-
Maria J Maristany
- Univ of Cambridge
-
Jerelle A Joseph
- University of Cambridge
-
Rosana Collepardo-Guevara
- University of Cambridge
-
Aleks Reinhardt
- University of Cambridge
-