Esther Hoffman Beller Lectureship (2022): Growth-rate dependent action of cell-wall targeting antibiotics

Antibiotics cure infections by killing bacteria or preventing them from growing – yet much remains to be understood about how this works. Many of the most widely used antibiotics target bacterial cell wall synthesis. These antibiotics often kill bacteria by causing them to explode, or lyse. We have investigated experimentally the efficacy of the cell wall targeting antibiotic mecillinam, which is used to treat urinary tract infections, for bacteria growing under different conditions. We show that a simple physiological model that takes into account the growth of bacterial cell volume and surface area, can explain non-trivial experimental observations.