Robots as Avatars of Evolution Under Stress

POSTER

Abstract

Experimental robo-biological physics can bring new insights into biological evolution. We present a development of hybrid analog/digital autonomous robots with mutable diploid dominant/recessive 6-byte genomes which exhibit pleiotropy because of multi-phenotype control by discrete genes. The robots are capable of death, rebirth and breeding. We map the quasi-steady state surviving local density of the robots onto a multi-dimensional abstract ``survival landscape''. We show it is generally necessary for robot survival on an externally and self-modified resource landscape to require the exchange of genes between the robots in addition to mutations, and we show via measurement of the Shannon genetic entropy that high genomic diversity and pleiotropy is essential for survival in a time and space stochastic environment. We propose that diploid gene robots with pleiotropy can act as avatars of diploid mammalian cells for novel programs of administration of drugs, and that a stochastic time and drug chemotherapy course would target cancer cells more effectively.

*his work was supported by the The National Natural Science Foundation of China (11974066 and 11674043), and the US National Science Foundation (PHY-1659940)

Presenters

  • Trung V Phan

    • Princeton University

Authors

  • Trung V Phan

    • Princeton University
  • Gao Wang

    • College of Physics, Chongqing University, Chongqing 401331, China
    • College of Physics, Chongqing University, Chongqing 400000, China
  • Shengkai Li

    • Georgia Institute of Technology
  • Jin Wang

    • Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China
  • Yan Peng

    • Research Institute of USV Engineering, Shanghai University,Shanghai, China, 200444
  • Daniel I Goldman

    • georgia tech
    • Georgia Institute of Technology
    • Georgia Institute of Technology, Atlalta, GA
    • Georgia Tech
  • Simon A Levin

    • Department of Environmental and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    • Princeton University
  • Kenneth J Pienta

    • Johns Hopkins University
  • Sarah Amend

    • Johns Hopkins Medical Institute, Baltimore MD
    • The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland
    • Johns Hopkins Medical Institute