Physics of Proteins III: Evolution and Function of Molecular Interactions

Presentations

• Conservative interactions in protein evolution

  ORAL · Invited

  March 15, 2022, 3:00 PM – March 15, 2022, 3:36 PM

  Presenters

  • Wouter D Hoff

    • Oklahoma State University-Stillwater
    • Okahoma State University

  Authors

  • Wouter D Hoff

    • Oklahoma State University-Stillwater
    • Okahoma State University

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• On the role of multiple states in allostery

  ORAL

  March 15, 2022, 3:36 PM – March 15, 2022, 3:48 PM

  Presenters

  • Eric Rouviere

    • University of Chicago

  Authors

  • Eric Rouviere

    • University of Chicago

  • Olivier Rivoire

    • Collège de France

  • Rama Ranganathan

    • University of Chicago

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• Quantifying protein interactions in a living organism

  ORAL

  March 15, 2022, 3:48 PM – March 15, 2022, 4:00 PM

  Presenters

  • Aniket Ravan

    • University of Illinois at Urbana-Champai

  Authors

  • Aniket Ravan

    • University of Illinois at Urbana-Champai

  • Yann R Chemla

    • University of Illinois at Urbana-Champaign

  • Martin Gruebele

    • University of Illinois at Urbana-Champaign

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• Many sequence-diverse protein domains switch between α-helix and β-sheet folds

  ORAL · Invited

  March 15, 2022, 4:00 PM – March 15, 2022, 4:36 PM

  Publication: "Pervasive fold switching in a ubiquitous protein superfamily" bioRxiv https://www.biorxiv.org/content/10.1101/2021.06.10.447921v1.abstract
  
  "A sequence-based method for predicting extant fold switchers that undergo α-helix ↔ β-strand transitions" (2021) Biopolymers https://doi.org/10.1002/bip.23471
  
  "A high-throughput predictive method for sequence-similar fold switchers" (2021) Biopolymers https://doi.org/10.1002/bip.23471
  
  "Extant fold-switching proteins are widespread" (2018) PNAS https://doi.org/10.1073/pnas.1800168115

  Presenters

  • Lauren Porter

    • National Institutes of Health - NIH

  Authors

  • Lauren Porter

    • National Institutes of Health - NIH

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• Preferential Exclusion and Hydration Dynamics in Compatible Osmolyte Solutions

  ORAL

  March 15, 2022, 4:36 PM – March 15, 2022, 4:48 PM

  Publication: Nimesh Shukla, Brianna Bembenek, Erika A. Taylor, and Christina M. Othon; "Conformational Consequences for Compatible Osmolytes on Thermal Denaturation" (2021)
  N. Shukla, C.J.S. Hect, J. Goeks, E. A. Taylor, C. M. Othon "Hydration Dynamics in Solutions of Cyclic Polyhydroxyl Osmolytes", Journal of Physical Chemistry B, 123 (40), 8472-8479. (2019)
  N. Shukla, E. Pomarico, L. Chen, M. Chergui, and C. M. Othon "Retardation of Bulk Water Dynamics by Disaccharide Osmolytes", J. Phys. Chem. B, 2016, 120 (35), pp 9477–9483. (2016)

  Presenters

  • Christina Othon

    • Ripon College

  Authors

  • Christina Othon

    • Ripon College

  • Nimesh Shukla

    • KLA

  • Erika Taylor

    • Wesleyan University

  • Brianna Bembenek

    • Ripon College

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• Quantifying Tubulin Heterodimer Assembly in vitro and Cells

  ORAL

  March 15, 2022, 4:48 PM – March 15, 2022, 5:00 PM

  Presenters

  • Yuhan Wang

    • University of Illinois at Urbana-Champaign

  Authors

  • Yuhan Wang

    • University of Illinois at Urbana-Champaign

  • Mahima Unnikrishnan

    • University of Illinois at Urbana-Champaign

  • Brooke Ramsey

    • University of Illinois at Urbana-Champaign

  • Catherine J Murphy

    • University of Illinois at Urbana-Champaign

  • Martin Gruebele

    • University of Illinois at Urbana-Champaign

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• Comparison of α-conotoxin free energy landscapes via simulation and dimensionality reduction

  ORAL

  March 15, 2022, 5:00 PM – March 15, 2022, 5:12 PM

  Presenters

  • Natalya Watson

    • Concordia University

  Authors

  • Ré A Mansbach

    • Concordia University

  • Natalya Watson

    • Concordia University

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• A Superstatistical Variational Model for Categorical Data: Applications to Protein Sequence Variation

  ORAL

  March 15, 2022, 5:12 PM – March 15, 2022, 5:24 PM

  Presenters

  • Hoda Akl

    • University of Florida

  Authors

  • Hoda Akl

    • University of Florida

  • Purushottam Dixit

    • University of Florida

  • Xiaochuan Zhao

    • University of Florida

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• A mechanochemical protein model reveals the principles of molecular discrimination.

  ORAL

  March 15, 2022, 5:24 PM – March 15, 2022, 5:36 PM

  Presenters

  • John M McBride

    • Institute for Basic Science

  Authors

  • John M McBride

    • Institute for Basic Science

  • Tsvi Tlusty

    • Institute for Basic Science

  • Jean-Pierre Eckmann

    • University of Geneva

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• Modeling sequence-space exploration and emergence of epistatic signals in protein evolution

  ORAL

  March 15, 2022, 5:36 PM – March 15, 2022, 5:48 PM

  Publication: https://arxiv.org/abs/2106.02441

  Presenters

  • Francesco Zamponi

    • CNRS and Ecole Normale Superieure, Paris

  Authors

  • Francesco Zamponi

    • CNRS and Ecole Normale Superieure, Paris

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