Micro-Fluidic Model and Experiments for Blood Drops on a Hyper-hydrophilic, Rapid Solidification Device, InnovaStrip, for Fast, Accurate, Cheap, Comprehensive Small Volume Blood Diagnostics using a SmartPhone App
ORAL
Abstract
Accurate Blood Diagnostics (BD) require 8-10 mL of blood per vial, expensive laboratories, and take days for results. Such large blood volumes lead to Hospital Acquired Anemia in 74% of patients and 100% of preemies. Hyper-hydrophilic coatings HemaDrop™ in a new handheld BD device, InnovaStrip™, yield cheap, fast, accurate BD by flattening and solidifying blood drops into Homogeneous Thin Solid Films (HTSF) in minutes without coagulation. HTSFs are reproducible unlike Dried Blood Spots. HTSFs are analyzed via hand-held X-Ray Fluorescence and Ion Beam Analysis. Both yield electrolytes, trace elements, toxic metals, and radionuclides to +/-10%. To analyze data quickly and accurately, an algorithm, Fast Accurate Blood Analysis (FABA), converts data in mg/dL, the unit for BD. InnovaStrip™ combined with FABA yields thus comprehensive BD. InnovaStrip™'s potential is significant for bringing fast, accurate, handheld, comprehensive BD to refugee camps and poor, underserved, and underprivileged areas with limited access to BD labs. In addition, rapid pathogen detection has also been developed in a parallel, handheld, inexpensive device, InnovaBug™ to be combined with InnovaStrip™.
*SiO2 Innovates, AccuAngle Analytics, National Sciences and Engineering Research Council of Canada.
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Publication: Herbots, N., Suresh, N., Khanna, S., Narayan, S., Chow, A., Sahal, M., . . . Kavanagh, K. (2019). Optimizing Homogeneous Thin Solid Films (HTSFs) from µL-Blood Droplets via Hyper-Hydrophilic Coatings (HemaDropTM) for Accurate Compositional Analysis via IBA, XRF, and XPS. MRS Advances, 4(46-47), 2489-2513. doi:10.1557/adv.2019.398
Presenters
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Arjun Sekar
- Arizona State University Dept. of Physics, SiO2 Innovates, MicroDrop Diagnostics