Volume segregation programming in a nematode's early embryogenesis
ORAL
Abstract
Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.
*This work was supported by the National Natural Science Foundation of China (Grant Nos. 11635002, 12090053, 32088101, U1430237, U1530401), the Hong Kong Research Grants Council (Grants Nos. HKBU12100118, HKBU12100917, HKBU12123716, HKBU12324716, HKBU12301514), and the HKBU Interdisciplinary Research Cluster Fund.
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Publication: 1. Guoye Guan†, Ming-Kin Wong, Zhongying Zhao, Lei-Han Tang*, Chao Tang*. Volume segregation programming in a nematode's early embryogenesis. Physical Review E, 104, 054409, 2021 (published)
2. Guoye Guan†, Ming-Kin Wong, Zhongying Zhao, Lei-Han Tang*, Chao Tang*. Speed and fate diversity tradeoff in nematode's early embryogenesis. arXiv, 2007.05723, 2021 (preprinted).
Presenters
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Guoye Guan
- Center for Quantitative Biology, Peking University