Elasticity from entanglements in branched actin

ORAL

Abstract

Branched actin networks exert pushing forces in eukaryotic cells, and adapt their stiffness to their environment. To understand the microscopic underpinnings of their response, we show using high-sensitivity micromanipulation experiments, numerical simulations and theory that unlike usual crosslinked networks, branched actin is dominated by the proliferation of interfilament contacts under compression. The tree-like topology of the networks make them particularly prone to developing growth-induced entanglements, and is thus key to their active adaptive mechanics.

*This work was supported by “Investissements d’Avenir” LabEx PALM (ANR-10-LABX-0039- PALM), ANR grant ANR-15-CE13-0004-03 and ERC Starting Grant 677532. My group belongs to the CNRS consortium CellTiss.

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Presenters

  • Martin Lenz

    • Universite Paris-Saclay
    • LPTMS, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay, France
    • CNRS
    • LPTMS, CNRS
    • LPTMS - CNRS, Université Paris-Saclay

Authors

  • Martin Lenz

    • Universite Paris-Saclay
    • LPTMS, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay, France
    • CNRS
    • LPTMS, CNRS
    • LPTMS - CNRS, Université Paris-Saclay

  • Mehdi Bouzid

    • CNRS
    • CNRS, University of Grenoble Alpes, Grenoble INP, 3SR Lab, F-38000 Grenoble, France
    • LPTMS - CNRS, Université Paris-Saclay

  • Cesar Valencia Gallardo

    • PMMH, ESPCI

  • Giuseppe Foffi

    • University of Paris-Saclay, CNRS, Laboratoire de Physique des Solides, 91405, Orsay
    • LPS - CNRS, Université Paris-Saclay

  • Julien Heuvingh

    • PMMH, ESPCI

  • Olivia du Roure

    • PMMH, ESPCI