Dual-mode nanoparticle MRI contrast agents

ORAL

Abstract

Contrast agents (CAs) can greatly improve the sensitivity and resolution in Magnetic Resonance Imaging (MRI). Various CAs are commercially available for both T1-weighted (e.g. gadolinium chelates) and T2-weighted (e.g. iron oxide nanoparticles) imaging. We have developed a series of CAs based on Fe and Mn oxo-metallic clusters encapsulated in polymer nanoparticles which display a large contrast enhancement for both T1- and T2- imaging. This creates the opportunity for dual-mode imaging combining T1- and T2- weighted images for enhanced sensitivity and resolution. We will discuss the synthesis of these materials and the development of image fusion algorithms for dual T1-T2 imaging.

*William and Karen Sonneborn Chair for Interdisciplinary Collaboration at Georgetown
National Institute Of Biomedical Imaging And Bioengineering of the National Institutes of Health under Award Number R15EB025538

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Presenters

  • Edward Van Keuren

    • Physics, Georgetown University
    • Department of Physics, Institute for Soft Matter Synthesis and Metrology, and Center for Translational Imaging, Georgetown University

Authors

  • Edward Van Keuren

    • Physics, Georgetown University
    • Department of Physics, Institute for Soft Matter Synthesis and Metrology, and Center for Translational Imaging, Georgetown University

  • Xiaowan Zheng

    • Department of Physics, Institute for Soft Matter Synthesis and Metrology, and Center for Translational Imaging, Georgetown University

  • Vidumin Dahanayake

    • Department of Chemistry and Center for Translational Imaging, Georgetown University

  • Trevor Lyons

    • Department of Chemistry and Center for Translational Imaging, Georgetown University

  • Sarah Stoll

    • Department of Chemistry and Center for Translational Imaging, Georgetown University

  • Christopher Albanese

    • Lombardi Cancer Center, Center for Translational Imaging, Georgetown University Medical Center. and Department of Radiology, Georgetown University Medical Center

  • Stanley Fricke

    • Lombardi Cancer Center, Center for Translational Imaging, Georgetown University Medical Center. and Department of Radiology, Georgetown University Medical Center

  • Olga Rodriguez

    • Lombardi Cancer Center and Center for Translational Imaging, Georgetown University Medical Center