Stochastic Lattice Model of the RAD51 Nucleoprotein Filament Formation on Single-Stranded DNA

POSTER

Abstract

Homologous recombination (HR) is one of the most enigmatic processes in DNA metabolism and is a fundamental driver of evolution. Its central step involves the search for homology between two DNA molecules and the subsequent exchange of the DNA strands.
We use a Monte Carlo model to study the statistics and dynamics of the recombinase filament nucleation, extension, and disassembly.
We use our developed computational toolbox for analyzing single-molecule data to build a predictive model to test different binding hypotheses

*Iowa Space Grant Consortium Collaborative Grant
University of Northern Iowa Graduate College Summer Fellowship
CHAS Research and Creativity Grant
University of Iowa FUTURE in BiomedecineProgram

Presenters

  • Ali Tabei

    • Univ of Northern Iowa

Authors

  • Mary Sutton

    • Univ of Northern Iowa

  • Colleen Caldwell

    • Biochemistry, University of Iowa

  • Maria Spies

    • Biochemistry, University of Iowa

  • Ali Tabei

    • Univ of Northern Iowa