Avalanching Upconverting Nanoparticles for Super Resolution Imaging

ORAL

Abstract

Photon avalanche (PA) is a photon energy upconversion excitation mechanism. It enables nonlinear dependence on excitation power, which is a key factor for various applications in photon science. One exciting application is that it suggests a possible approach to super-resolution imaging with a simple confocal microscope system. Here, we introduce avalanching upconverting nanoparticles (AUCNPs), NaYF4 nanocrystals doped with Thulium ions. The presence of PA was verified by time-resolved photoluminescence measurement. Upon the exitation of 1064nm laser, the resolution of 2-dimensional photoluminescence map was resolved to 90nm as a result of high nonlinearity, more than 4 times of diffraction-limited imaging resolution. AUCNPs are thus a promising new method for super resolution bioimaging.

*This material is based upon work supported by the National Science Foundation Graduate Research Fellowship (NSF GRFP) under Grant No.DGE - 1644869. Portions of this research were supported by the Global Research Laboratory (GRL) Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (no. 2016911815).

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Presenters

  • Emma Xu

    • Columbia University

Authors

  • Emma Xu

    • Columbia University

  • Changhwan Lee

    • Columbia University

  • Kaiyuan Yao

    • Columbia University
    • Mechanical Engineering, Columbia University

  • Bruce Cohen

    • Lawrence Berkeley National Laboratory

  • Emory Chan

    • Lawrence Berkeley National Laboratory

  • Yung Doug Suh

    • Korea Research Institute of Chemical Technology

  • P. James Schuck

    • Columbia University
    • Mechanical Engineering, Columbia University