DNA Local Flexibility Dependent Formation of Liquid-like Droplets
ORAL
Abstract
Associative phase separation of biomacromolecules like proteins and nucleic acids into liquid-like droplets, termed liquid-liquid phase separation (LLPS), has been linked to sans lipid-membrane intracellular organization as well as aggregation mediated diseases. In this work, we have studied the role of sequence-dependent DNA flexibility in LLPS of multiple interacting components. We find that DNA local flexibility, encoded by the DNA sequence, not simply the overall charge density, determines the phase behavior in such systems.
*The authors thank taxpayers who supported this work through the Korean Institute for Basic Science, project code IBS-R020-D1.
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Presenters
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Anisha Shakya
- Center for Soft and Living Matter, Institute for Basic Science