DNA-directed hydrogel deformation
· Invited
Abstract
DNA polymerization reactions within DNA-crosslinked hydrogels can direct the dramatic shape change of DNA-crosslinked hydrogels, leading of up to 100-fold changes in gel volume. The well-understood kinetics
and thermodynamics of these reactions and of DNA transport make it possible to design a myriad of molecular scale reactions and to study the emergent shape-change behavior of these reactions at the millimeter scale. And because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, understanding DNA-directed hydrogel shape change introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs.
and thermodynamics of these reactions and of DNA transport make it possible to design a myriad of molecular scale reactions and to study the emergent shape-change behavior of these reactions at the millimeter scale. And because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, understanding DNA-directed hydrogel shape change introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs.
*DOE Early Career 221874
NSF EFRI 1830893
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Presenters
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Rebecca Schulman
- Johns Hopkins University