Electron Transport Through Peptides and Blue-Copper Azurins

ORAL

Abstract

Inspired by recent experiments [1], we present a theoretical study of the electron transport through heptapeptides based on alanine, glutammic acid, lysine and tryptophan. For them all, we found very low conductance values and we ascribed them to the high localization of their frontier orbitals [2]. We also show a combined experimental and theoretical work on the transport through a bluecopper azurin and a mutant; we found that the conductance channels in the single-protein electrical contact can be finely tuned by performing point-site mutations in the outer protein structure [3].

[1] Sepunaru, L.; Refaely-Abramson, S.; Lovrincic, R.; Gavrilov, Y.; Agrawal, P.;Levy, Y.; Kronik, L.; Pecht, I.; Sheves, M.; Cahen, D., J. Am. Chem. Soc. 2015, 137,9617
[2] L. A. Zotti, and J. C. Cuevas, submitted.
[3] M. P. Ruiz, A. C. Aragonés, N. Camarero, J.G. Vilhena, M. Ortega,L. A. Zotti, R. Peréz,J. C. Cuevas, P. Gorostiza, I. Diez Pérez, J. Am. Chem. Soc., DOI: 10.1021/jacs.7b06130

*Spanish MINECO (MAT2014-58982-JIN)
Red Española de Supercomputación (RES) - Minotauro and Marenostrum supercomputers (BSC,Barcelona)

Presenters

  • Linda Angela Zotti

    • Dept. de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid

Authors

  • Linda Angela Zotti

    • Dept. de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
  • Marta P. Ruiz

    • The Barcelona Institute of Science and Technology (BIST), Institute for Bioengineering of Catalonia (IBEC)
  • Albert C. Aragonés

    • The Barcelona Institute of Science and Technology (BIST), Institute for Bioengineering of Catalonia (IBEC)
  • Nuria Camarero

    • The Barcelona Institute of Science and Technology (BIST), Institute for Bioengineering of Catalonia (IBEC)
  • Jose Guilherme Vilhena

    • Dept. de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
  • Maria Ortega

    • Dept. de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
  • Ruben Perez

    • Dept. de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
  • Juan Carlos Cuevas

    • Departamento de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
    • Dept. de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
  • Pau Gorostiza

    • The Barcelona Institute of Science and Technology (BIST), Institute for Bioengineering of Catalonia (IBEC)
  • Ismael Diéz-Pérez

    • The Barcelona Institute of Science and Technology (BIST), Institute for Bioengineering of Catalonia (IBEC)