DNA translocation measurements through low-capacitance solid-state nanopore chips at high bandwidths

ORAL

Abstract

We perform DNA translocation measurements with low-noise solid state nanopore chips.~ We obtain higher ion current signal-to-noise ratio and better resolution in ion current signals than previously reported in solid state nanopores at high bandwidths with chip capacitance lowering techniques of applying extra insulation on the chip surface. We show measurements of ion current~ during translocation of DNA molecules through thin silicon nitride (SiN) nanopores of small diameters at megahertz bandwidths with enhanced ionic signal-to-noise ratios.~~We further discuss how these results possibly pave the way towards identifying intramolecular DNA sequences with solid-state nanopores.

Authors

  • Chen-Chi Chien

    • University of Pennsylvania
  • David Niedzwiecki

    • University of Pennsylvania
  • Bartholomeus Machielse

    • University of Pennsylvania
    • Univ of Pennsylvania
  • Adrian Balan

    • Univ of Pennsylvania
    • University of Pennsylvania
  • Jianxun Lin

    • Columbia University
  • Peijie Ong

    • Columbia University
  • Kenneth Shepard

    • Columbia University
  • Marija Drndic

    • University of Pennsylvania, Department of Physics and Astronomy
    • University of Pennsylvania
    • Univ of Pennsylvania