Graphene Nanopres for DNA Fingerprinting

ORAL

Abstract

The recent progress in nanopore experiments with transverse current is important for the development of fast, accurate and cheap finger-printing techniques for single nucleotide. Despite its enormous potential for the next generation DNA sequencing technology, the presence of large noise in the temporal spectrum of transverse current remains a big challenge for getting highly accurate interpretation of data. In this paper we present our {\it abinitio} calculations, and propose graphene based device for DNA fingerprinting. We calculate transmission current through graphene for each DNA base (A,C,G,T). As shown in our work, a proper time-series analysis of a signal provides a higher quality information in identifying single bio-molecule is translocating through the nanopores.

*This work is supported by LANL, Nordita, US DOE, AFOSR, and NIH.

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Authors

  • Towfiq Ahmed

    • Los Alamos National Laboratory

  • Alexander V. Balatsky

    • Los Alamos National Laboratory, NORDITA
    • Los Alamos National Lab
    • Los Alamos National Laboratory and Nordic Institute of Theoretical Physics (Nordita)

  • J.T. Haraldsen

    • Los Alamos National Laboratory

  • Ivan K. Schuller

    • Department of Physics and Center for Advanced Nanoscience, University of California-San Diego, USA
    • University of California San Diego
    • Center for Advanced Nanoscience, Department of Physics, University of California, San Diego
    • Department of Physics and Astronomy, University of California San Diego, 9500 Gilman Dr., San Diego, La Jolla, CA 92093, U.S.A
    • University of California, San Diego
    • University of California - San Diego

  • M. Di Ventra

    • University of California, San Diego

  • K.T. Wikfeldt

    • Nordic Institute of Theoretical Physics (Nordita)