Polymerization and oscillation stuttering in a filamentous model of the subcellular Min oscillation

ORAL

Abstract

We present a computational model of the {\em E. coli} Min oscillation that involves polymerization of MinD filaments followed by depolymerization stimulated by filament-end zones of MinE. Our stochastic model is fully three-dimensional, and tracks the diffusion and interactions of every MinD and MinE molecule. We recover self-organized Min oscillations. We investigate the experimental phenomenon of oscillation stuttering, which we relate to the disruption of MinE tip-binding at the filament scale.

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Authors

  • Andrew Rutenberg

    • Dalhousie University

  • Supratim Sengupta

    • Jawaharlal Nehru University

  • Anirban Sain

    • Indian Institute of Technology - Bombay

  • Julien Derr

    • Harvard University