Terminating Ventricular Fibrillation Using Pulsed Far-Field Stimulation in Whole Rabbit Hearts

ORAL

Abstract

During life-threatening cardiac fibrillation, chaotic spatio-temporal dynamics is mediated by vortex-like rotating waves. Current defibrillation strategies rely on global control through high-energy shocks, which may have severe side-effects including traumatic pain and tissue damage. Far-field antifibrillation pacing terminates fibrillation using a train of low-energy electric pulses [1,2]. Using optical mapping in isolated rabbit heart preparations, we evaluate the efficiency and robustness of this approach. We found that a series of pulses at low energies ($<$ 2.0 J) is sufficient to extinguish ventricular fibrillation with a success rate of 95{\%}. We will discuss the physical mechanisms involved.\\[4pt] [1] F.H. Fenton et al, Circulation 120 467-476 (2009).\\[0pt] [2] A. Pumir et al., Phys. Rev. Lett. 99, 208101 (2007).

*We gratefully thank the BMBF, the NIH and the Max Planck Society for funding.

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Authors

  • Amgad Squires

    • Cornell University

  • Daniel Hornung

    • Max Planck Institute for Dynamics and Self-Organization

  • Philip Bittihn

    • Max Planck Institute for Dynamics and Self-Organization

  • Dong Xia Wu

    • Max Planck Institute for Dynamics and Self-Organization

  • Valentin Krinsky

    • Max Planck Institute for Dynamics and Self-Organization

  • Markus Zabel

    • University Hospital G\&#034;ottingen

  • Eberhard Bodenschatz

    • Max Planck Institute for Dynamics and Self-Organization
    • MPI for Dynamics and Self-Organization, Goettingen and LASSP, Cornell University, Ithaca
    • LASSP, Cornell University, Ithaca and MPI for Dynamics and Self-Organization, Goettingen
    • LASSP, Cornell University, Ithaca and MPI for Dynamics and Selforganization, Goettingen

  • Stefan Luther

    • Max Planck Institute for Dynamics and Self-Organization