Synchronization of synthetic gene oscillators

ORAL

Abstract

Synchronized clocks are of fundamental importance in the coordination of rhythmic behavior among individual elements in a community. We describe an engineered gene circuit with intercellular coupling that generates synchronized oscillations in a population of bacteria. Using micro?uidic devices tailored for cellular populations at differing length scales, we investigate the collective synchronization properties along with spatiotemporal waves occurring on millimeter scales. We use computational modeling to quantitatively describe the observed phenomena.

*This work was supported by the National Institutes of Health and General Medicine (GM69811), the DOE CSGF fellowship (TD), and CONACyT (Mexico, grant 184646, OMP)

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Authors

  • Lev S. Tsimring

    • University of California, San Diego

  • Tal Danino

    • University of California, San Diego

  • Octavio Mondragon-Palomino

    • University of California, San Diego

  • Jeff Hasty

    • University of California, San Diego