The Assembly of Cyclopeptide-Polymer Conjugates and Block Polymer

POSTER

Abstract

The co-assembly of cyclopeptide-polymer conjugates and block polymer affords a simple route to generate hierarchical structures with molecular level control over the assemblies. By coupling synthetic homopolymer to a preformed cyclic (D-alt-L)-R- octapeptide, a family of coil-ring-coil bioconjugates was synthesized. The controlled self-assembly of the conjugate leads to uniform nanoparticle structures, 2.5-3nm in height and 25- 30nm in diameter. The assembly of blends of cyclopeptide-polymer conjugates and block polymer has been further investigated. The co-assembly of cyclopeptide-polymer conjugates and diblock copolymer provide a base to generate nanoporous materials and improve our understanding in the self-assembly of mutli- component hybrid systems.

Authors

  • Nana Zhao

    • Department of Materials Science and Engineering, University of California

  • Brett Helms

    • Material Sciences Division, Lawrence Berkeley National Laboratory

  • Ting Xu

    • Dept. of Materials Science and Engineering, University of California, Berkeley
    • University of California, Berkeley
    • Dept. of Materials Science and Engineering, UC Berkeley
    • Department of Materials Science and Engineering, Department of Chemistry, University of California, Berkeley
    • Department of Materials, UC Berkeley
    • Materials Science and Engineering, Department of Chemistry, University of California, Material Sciences Division, Lawrence Berkeley National Lab
    • UC Berkeley