Magnetite-Alginate-AOT nanoparticles based drug delivery platform

POSTER

Abstract

Iron oxide having the magnetite structure is a widely used biomaterial, having applications ranging from cell separation and drug delivery to hyperthermia. In order to increase the efficacy of drug treatments, magnetite nanoparticles can be incorporated into a composite system with a surfactant-polymer nanoparticle, which can act as a platform for sustained and enhanced cellular delivery of water-soluble molecules. Here we report a composite formulation based on magnetite and Alginate-aerosol OT (AOT) nanoparticles formulated using an emulsion-cross-linking process loaded with Rhodamine 6G [1]. We prepared two set of nanoparticles by using Ca$^{2+}$ or Fe$^{2+}$ to cross-link the alginate polymer. Additionally, we added $\sim $8 nm diameter Fe$_{3}$O$_{4}$ magnetic nanoparticles prepared by a soft chemical method to these alginate-AOT nanoparticles. The resulting composites were superparamagnetic at room temperature, with a saturation magnetization of approximately 0.006 emu/g of solution. We will present detailed studies on the structural and magnetic properties of these samples. We will also discuss HPLC measurements on Rhodamine uploading in these composites. [1] M.D.Chavanpatil, Pharmaceutical Research, vol.24, (2007) 803.

Authors

  • R. Regmi

    • Department of Physics and Astronomy, Wayne State University

  • C. Sudakar

    • Wayne State University
    • Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201
    • Wayne State University, Detroit, MI
    • Dept. of Physics and Astronomy, Wayne State University, Detroit, MI 48201 USA.
    • Department of Physics and Astronomy, Wayne State University
    • Department of Physics and Astronomy Wayne State University

  • A. Dixit

    • Department of Physics and Astronomy, Wayne State University

  • R. Naik

    • Wayne State University
    • Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201
    • Wayne State University, Detroit, MI
    • Dept. of Physics and Astronomy, Wayne State University, Detroit, MI 48201 USA.
    • Department of Physics and Astronomy, Wayne State University
    • Department of Physics and Astronomy Wayne State University

  • G. Lawes

    • Wayne State University
    • Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201
    • Dept. of Physics and Astronomy, Wayne State University, Detroit, MI 48201 USA.
    • Department of Physics and Astronomy, Wayne State University
    • Department of Physics and Astronomy Wayne State University

  • U. Toti

    • College of Pharmacy, University of Minnesota

  • J. Panyam

    • College of Pharmacy, University of Minnesota

  • P.P. Vaishnava

    • Kettering University