Monte Carlo Simulations of X-ray Sources and Nano-moieties for Radiation Therapy and Diagnostics (Theranostics)

X-ray therapy and diagnostics devices generate broadband radiation that is not efficient over the entire range and is eiher tool low or too high in energy. Monochromatic or quasi-monochromatic devices may target specific atomic features in high-Z nanoparticles that may absorb radiation more efficiently. We simulate the X-ray-nanoparticle interactions using a modified version of the general purpose Monte Carlo code GEANT4-DNA to compute single-strand-breakups (SSB) and double-strand-breakups (DSB) to demonstrate the efficacy of X-ray radiosenstization of varioius combination of nano-moiteties such as gold nanoparticles.