Computational Approach for Quantifying Structural Disorder in Biomolecular Lattices

ORAL

Abstract

We have developed a novel computational approach for quantifying structural disorder in biomolecular lattices with nonlinear susceptibility based on analysis of polarization-modulated second harmonic signal. Transient, regional disorder at the level of molecular organization is identified using a novel signal-processing algorithms sufficiently compact for near real-time analysis with a desktop computer. Global disorder and regional disorder within the biostructure are assessed and scored using a multiple methodologies. Experimental results suggest our signal processing method represents a robust, scalable tool that allows us to detect both regional and global alterations in signal characteristics of biostructures with a high degree of discrimination.

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Authors

  • Clayton Bratton

    • University of California, Davis - Physics

  • Karen Reiser

    • University of California, Davis - Neurosurgery

  • Andre Knoesen

    • University of California, Davis - Electrical and Computer Engineering

  • Diego Yankelevich

    • University of California, Davis - Electrical and Computer Engineering

  • Mingshi Wang

    • University of California, Davis - Electrical and Computer Engineering

  • Israel Rocha - Mendoza

    • Cardiff University, Cardiff, Wales - Cardiff School of Biosciences